Cooper Tire & Rubber Company is the lead entity in a consortium that is working under a $6.9 million Biomass Research and Development Initiative (BRDI) grant to advance science in the areas of Guayule plant genetics, agronomics, rubber production and utilization of rubber and other co-products from Guayule. Guayule is being studied as a potential alternative to Hevea natural rubber in the manufacture of tires. A major part of the grant is centered on production and testing of a guayule rubber based tire, and significant progress toward this goal has been achieved since the grant was initiated in 2012. The environmental, social, and economic effects of commercialization of Guayule in the tire industry will also be the subject of a life cycle analysis report, which is part of the grant and will be published at a later date. This presentation will provide an update on the Guayule rubber based tire development work, including a review of some of the project challenges as well as its accomplishments to date.