Rubber-to-substrate bonding refers to the process of joining rubber, adhesive, and substrate. This is typically done through application of heat and pressure. The type of rubber, adhesive, and substrate vary depending on end-use application of the bonded article. LORD Chemlok® adhesives have been the market leader in the area of rubber-to-substrate bonding for over 55 years with proven performance and broad range of product offerings. With such a wide selection of products, selecting the right adhesive system can be daunting. The objective of this paper is to provide a guide to selecting an adhesive for a specific application and review the important concepts behind rubber-to-substrate bonding.