Technical Paper Archive

This site contains all papers presented at Rubber Division, ACS Technical Meetings from 2000-2018. Meetings prior to 2000 are incomplete and papers are added as they are digitized.

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Improved Medical Stopper Solutions with High Performance, Anionic Isoprene Rubber


Event: 182nd Technical Meeting
Location: Cincinnati, OH
Date: October 09, 2012
Author: George A. Anthony*, Philippe Henderson*, Dr. Marc Hein*
Paper Number: 33

Price: $20.00

  • Natural rubber (NR) has been the material-of-choice in many medical applications including medical stoppers. However, health care providers and the general population have become more aware of NRis naturally-occurring impurities and proteins, which can result in allergenic sensitivities. As a result, medical device manufacturers, which includes the medical stopper industry, seek synthetic rubber alternatives to replace NR and are also gearing up to deal with the next wave of aggressive and sensitive drugs, stricter packaging performance requirements, and rising safety standards. This paper will compare the chemistry and performance of four rubber products that are currently used in medical stoppers, which include anionic IR, polymerized with an alkyl-lithium initiator, Ziegler-Natta IR, polymerized with titaniumlaluminum catalyst, chlorobutyl rubber, and bromobutyl rubber. The criterion for the study was based on common medical stopper test protocols. The results will demonstrate that anionic isoprene rubber delivers a unique combination of advantages including the absence of natural rubber proteins present in NR, an odor-free formulation with low residual metals and no residual catalysts, low needle insertion force, and minimal risk of rubber fragmentation (coring) and medication contamination due to needle insertion.

    Papers from 182nd Technical Meeting

    Items from 182nd Technical Meeting